by ACDSee Photo Manager V12.0 (build 344) - CORE Download Pc - Android Emulator.[Inhibition of NK-cell activity by interferon in uremic patients].
Interferon (IFN)-alpha has been used clinically to treat various malignancies. IFN is also known to induce a number of pharmacological effects. However, the effect of IFN on natural killer (NK) cell activity is not known. The immunological function of various peripheral blood lymphocytes in uremic patients with various types of dialysis was examined before and after IFN therapy. A rapid recovery of leukocyte count was observed after IFN therapy, and lymphocyte subsets were changed to normal. NK cell activity was markedly decreased in these patients, and this reduction was restored after IFN therapy. Lymphocytes from dialysis patients did not show significant cytotoxicity, whereas those from healthy subjects showed relatively high cytotoxicity. IFN reduced NK cell activity in healthy subjects, but not in dialysis patients. NK activity recovered to normal after IFN therapy in dialysis patients. These findings suggest that IFN therapy increases the ratio of active cytotoxic lymphocytes and increases the cytotoxicity of those lymphocytes in the circulation, as well as increasing lymphocyte number. These phenomena may explain the beneficial effects of IFN therapy in uremic patients.Molecular dynamics of lipid bilayers and proteins: a new method for simulation studies.
A new method for the molecular dynamics simulation of lipid bilayers and proteins is described. The simulation system consists of a cubic box containing a trilayer lipid membrane and a single spherical protein. Both the lipid bilayer and the protein are solvated in a solvent box containing a number of water molecules. The molecular interactions of the water molecules with the protein and with the lipid membranes are specified. The interaction with the lipid membrane is described by the van der Waals interaction, the electrostatic interaction, and the hydrophobic interaction. The interaction between the lipid membrane and the protein is described by the van der Waals interaction. The interaction between the lipid bilayer and the protein is described by the van der Waals interaction and the electrostatic interaction. Interactions between the lipid membranes are described by the van der Waals interaction, the electrostatic interaction, the hydrophobic interaction, and the hydrogen bonds. The method is tested by studying the stability of the lipid bilayer, the structure of the lipid be359ba680
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